N-(4-{4-[ethyl(heptyl)amino]-1-hydroxybutyl}phenyl)methanesulfonamide
Ibutilide fumarate
CAS: 122647-32-9
Molecular Formula: (C20H36N2O3S)2.C4H4O4
N-(4-{4-[ethyl(heptyl)amino]-1-hydroxybutyl}phenyl)methanesulfonamide - Names and Identifiers
| Name | Ibutilide fumarate |
| Synonyms | D00648 Corvert (tn) Ibutibide Fumarate Ibulitide fumarate Ibutilide fumarate IBUTILIDE FUMRTATE Ibutilide fumarate (usan) N-(4-{4-[ethyl(heptyl)amino]-1-hydroxybutyl}phenyl)methanesulfonamide N-[4-[4-(ethyl-heptyl-amino)-1-hydroxy-butyl]phenyl]methanesulfonamide fumarate (±)-N-[4-[4-(Ethylheptylamino)-1-hydroxybutyl]phenyl]methanesulfonamide hemifumarate |
| CAS | 122647-32-9 |
| EINECS | 687-381-2 |
| InChI | InChI=1/C20H36N2O3S.C4H4O4/c1-4-6-7-8-9-16-22(5-2)17-10-11-20(23)18-12-14-19(15-13-18)21-26(3,24)25;5-3(6)1-2-4(7)8/h12-15,20-21,23H,4-11,16-17H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1- |
N-(4-{4-[ethyl(heptyl)amino]-1-hydroxybutyl}phenyl)methanesulfonamide - Physico-chemical Properties
| Molecular Formula | (C20H36N2O3S)2.C4H4O4 |
| Molar Mass | 885.24 |
| Melting Point | 112-117?C |
| Boling Point | 522.4°C at 760 mmHg |
| Flash Point | 269.7°C |
| Solubility | DMSO 89 mg/mL Water 89 mg/mL Ethanol 89 mg/mL |
| Vapor Presure | 9.71E-12mmHg at 25°C |
| Appearance | White-like to brown powder or solid |
| Color | off-white to tan |
| Maximum wavelength(λmax) | 267nm(EtOH)(lit.) |
| Merck | 14,4883 |
| Storage Condition | 2-8°C |
| MDL | MFCD01715410 |
| Use | This product is for scientific research only and shall not be used for other purposes. |
N-(4-{4-[ethyl(heptyl)amino]-1-hydroxybutyl}phenyl)methanesulfonamide - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
| WGK Germany | 1 |
| RTECS | PB0475700 |
| HS Code | 2935904000 |
N-(4-{4-[ethyl(heptyl)amino]-1-hydroxybutyl}phenyl)methanesulfonamide - Nature
Open Data Verified Data
crystallized from acetone, melting point 117-119 °c. UV maximum absorption (95% ethanol):228nm, 267nm (e16670,894)
Last Update：2024-01-02 23:10:35
N-(4-{4-[ethyl(heptyl)amino]-1-hydroxybutyl}phenyl)methanesulfonamide - Preparation Method
Open Data Verified Data
4-(4-methanesulfonylaminophenyl) -4-carbonyl acetic acid dissolved in dimethylformamide, 1-hydroxybenzotriazole and dicyclohexylcarbodiimide were added under stirring, further N-ethyl N-heptanamine was added and the resulting compound was reduced to give ibutilide.
Last Update：2022-01-01 09:10:16
N-(4-{4-[ethyl(heptyl)amino]-1-hydroxybutyl}phenyl)methanesulfonamide - Introduction
Ibutilide Fumarate is the third type of antiarrhythmic drug, mainly used for acute new obstruction of atrial fibrillation (atrial fibrillation)/atrial flutter (atrial flutter), suitable for recent episodes of atrial fibrillation or atrial flutter reversal into sinus rhythm, slow induction of inward sodium current, which will prolong the action potential and refractory period of myocardial cells.
Last Update：2022-10-16 17:12:52
N-(4-{4-[ethyl(heptyl)amino]-1-hydroxybutyl}phenyl)methanesulfonamide - Use
Open Data Verified Data
developed by Phamlacia 8L Upjohn in Switzerland and USA, launched in USA in 1996. Antiarrhythmic.
Last Update：2022-01-01 09:10:17
N-(4-{4-[ethyl(heptyl)amino]-1-hydroxybutyl}phenyl)methanesulfonamide - Reference Information
| overview | ibutilide fumarate (Ibutilide Fumarate) is a class III antiarrhythmic drug with new ion channel activity developed by Pharmacia & Upjohn in the United States. Approved by FDA in December 1995, it was listed in the United States in April 1996 with the Convert trade name. |
| use | ibutilide fumarate has become the first choice for the treatment of newly occurring atrial fibrillation and atrial flutter, and is currently the only class III antiarrhythmic drug approved for the conversion of atrial fibrillation and atrial flutter in the United States. The efficacy of this product is better than that of antiarrhythmic drugs such as amiodarone, propoxone, procainamide, sotalol, and ethylamine iodolone. |
| biological activity | Ibutilide Fumarate (U-70226E) is the third type of antiarrhythmic drug, mainly used for acute new obstruction of atrial fibrillation (atrial fibrillation)/atrial flutter (atrial flutter), suitable for recent episodes of atrial fibrillation or atrial flutter reversal into sinus rhythm, slow induction of inward sodium current, this prolongs the action potential and refractory period of cardiomyocytes. |
| target | TargetValue Sodium channel |
| Target | Value |
Last Update：2024-04-09 19:05:04
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Product Name: Ibutilide Fumarate Visit Supplier Webpage Request for quotationCAS: 122647-32-9
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